Immunosuppressive Treatment for Lupus Nephritis: Long-Term Results in 178 Patients
نویسندگان
چکیده
منابع مشابه
Immunosuppressive Treatment for Lupus Nephritis: Long-Term Results in 178 Patients
Lupus nephritis is one of the most severe Systemic Lupus Erythematosus features, defining treatment modality and prognosis. Our retrospective study, including 178 patients treated for lupus nephritis during 23 years with mostly cyclophosphamide-based initial regimens followed by azathioprine or mycophenolic acid, demonstrates 84.8% of renal response with 19.2% of flares, 15-year patient surviva...
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BACKGROUND Combination therapy with cytotoxic drugs and corticosteroids reduces the risk for renal failure in patients with proliferative lupus nephritis (PLN), but uncertainty remains about the best mode of immunosuppression and its long-term effects. We report long-term results of combined azathioprine-prednisolone treatment for PLN, which has been the therapy of choice for the treatment of P...
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OBJECTIVES To evaluate the prevalence of carotid plaques in patients with long-term lupus nephritis (LN). METHODS Intima-media thickness (IMT) and carotid plaques were evaluated with ultrasound in 75 patients after a follow-up of LN of 158+/-106 months and in 75 sex -and age-matched controls. Traditional and non-traditional atherosclerotic risks factors were also tested. RESULTS IMT was not...
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The purposes of the present study have been to analyse the presenting features, response to therapy and survival of myeloma patients aged 70 years or more, in comparison to younger patients. From January 1985 to December 1989, 487 patients with multiple myeloma (MM) were randomized to receive melphalan and prednisone (MP) versus alternating cycles of vincristine, cyclophosphamide, melphalan, an...
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OBJECTIVE In the Euro-Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high-dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low-dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 mon...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2016
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2016/7407919